Medical Weight Loss in St. Louis, MO
At ManUp / WomanUp, we understand that sustainable weight loss is more than willpower—it's medical science. As a fully licensed clinic with experienced medical providers on staff, we combine cutting-edge GLP-1 medications with traditionally proven weight loss treatments to deliver extraordinary results under careful medical supervision.
With five convenient locations in O'Fallon, St. Peters, Ellisville, Fenton, and Washington, MO, our mission is to help patients achieve lasting weight loss transformation through evidence-based medical interventions that work with your body's natural processes.
Medical weight loss isn't just about the number on the scale—it's about reclaiming your health, confidence, and quality of life. For many people, persistent weight gain, food cravings, metabolic slowdown, or inability to lose weight despite diet and exercise efforts signal that medical intervention may be necessary to break through physiological barriers.
Through comprehensive medical evaluation, personalized treatment protocols combining multiple medications, and ongoing medical supervision, ManUp and WomanUp are committed to guiding patients from frustrating weight loss plateaus to achieving their goal weight safely and sustainably.
Why Medical Weight Loss Works When Diet and Exercise Alone Don't
Weight management is controlled by complex hormonal and neurological pathways that regulate appetite, metabolism, fat storage, and energy expenditure. When these systems are dysregulated—whether due to genetics, hormonal changes, insulin resistance, or metabolic adaptation—traditional diet and exercise approaches often fall short.
Medical weight loss addresses the root physiological causes of weight gain and difficulty losing weight, rather than relying solely on caloric restriction and increased activity.
Signs You May Benefit from Medical Weight Loss
Some of the most common indicators include:
- Persistent weight gain despite diet and exercise efforts
- Intense food cravings and difficulty controlling appetite
- Metabolic slowdown or weight loss plateaus
- Insulin resistance or pre-diabetic markers
- Hormonal imbalances affecting weight
- Emotional or stress eating patterns
- Previous weight loss followed by rapid regain
- BMI over 27 with health complications or over 30
These challenges aren't character flaws—they're biological realities that respond to targeted medical treatment. The good news is that with proper medical evaluation and treatment, sustainable weight loss is achievable.
Our Comprehensive Medical Weight Loss Approach
At ManUp / WomanUp, medical weight loss is not a cookie-cutter program. We start with a thorough medical evaluation including detailed health history, comprehensive lab work, and assessment of your weight loss goals to create a personalized treatment protocol.
Our licensed medical providers utilize both revolutionary GLP-1 medications and traditionally proven weight loss medications, often combining treatments for enhanced effectiveness under careful medical supervision.
This integrated medical approach ensures that each patient receives care that is safe, effective, and designed to optimize both weight loss results and overall metabolic health.
Advanced GLP-1 Medications: The Future of Weight Loss
GLP-1 (glucagon-like peptide-1) receptor agonists represent a breakthrough in medical weight loss treatment. These medications work by mimicking hormones naturally produced in your intestines that regulate blood sugar, slow gastric emptying, and signal satiety to the brain.
Semaglutide (Ozempic/Wegovy)
Originally developed for diabetes management, semaglutide has shown remarkable weight loss results in clinical studies. Patients typically experience:
- Significant appetite reduction
- Enhanced satiety and portion control
- Average weight loss of 15-20% of body weight
- Improved metabolic markers including blood sugar and blood pressure
Tirzepatide (Mounjaro/Zepbound)
The newest GLP-1 medication, tirzepatide also targets GIP (glucose-dependent insulinotropic polypeptide) receptors, providing dual action for enhanced results:
- Superior weight loss compared to semaglutide in clinical trials
- Average weight loss of 20-25% of body weight
- Excellent glycemic control
- Reduced cardiovascular risk factors
Retatrutide (Investigational)
As an emerging triple-receptor agonist targeting GLP-1, GIP, and glucagon receptors, retatrutide shows promise for even greater weight loss results in ongoing clinical studies.
Proven Traditional Weight Loss Medications
While GLP-1 medications represent cutting-edge treatment, we also utilize traditionally effective FDA-approved medications with decades of proven results:
Phentermine
The most widely prescribed weight loss medication, phentermine is a powerful appetite suppressant that:
- Reduces hunger and food cravings
- Increases energy and focus
- Enhances metabolic rate
- Provides rapid initial weight loss results
Phendimetrazine
A longer-acting appetite suppressant offering:
- Extended appetite control throughout the day
- Less frequent dosing requirements
- Sustained energy without crashes
- Effective for patients who build tolerance to phentermine
Metformin
Originally a diabetes medication, metformin supports weight loss through:
- Improved insulin sensitivity
- Reduced glucose production by the liver
- Decreased appetite and carbohydrate cravings
- Enhanced fat oxidation
Naltrexone
An opioid receptor antagonist that helps with weight loss by:
- Reducing food reward pathways in the brain
- Decreasing binge eating and emotional eating
- Blocking the pleasurable response to high-calorie foods
- Supporting long-term behavior modification
The ManUp/WomanUp Advantage: Combination Therapy Under Medical Supervision
What sets our program apart is our ability as a fully licensed medical clinic to safely combine these medications for extraordinary results. Our licensed medical providers can prescribe:
- GLP-1 medications combined with appetite suppressants for enhanced hunger control
- Metformin with GLP-1 drugs for improved metabolic function
- Naltrexone combinations to address both appetite and food reward behaviors
- Customized medication protocols based on individual patient needs and responses
This combination approach, available only under proper medical supervision, allows us to target multiple pathways simultaneously for faster, more comprehensive weight loss results while maintaining safety through regular monitoring and adjustment.
The Four Phases of Weight Loss Transformation
Every patient's journey is unique, but our years of experience have identified four common phases of medical weight loss transformation:
Phase 1: Breaking Through Barriers
Phase 1 focuses on overcoming the physiological barriers that have prevented successful weight loss. During this phase:
- We conduct comprehensive medical evaluation and lab work
- Initial medication protocols are established
- Appetite reduction and craving control typically begin within days
- Early weight loss results provide motivation and momentum
- Most patients lose 5-15 pounds in the first month
This phase is about breaking the cycle of failed diet attempts and establishing medical intervention that works with your body's biology.
Phase 2: Achieving Steady Progress
Once initial barriers are overcome, Phase 2 focuses on consistent, sustainable weight loss. Patients typically experience:
- Steady weight loss of 2-4 pounds per week
- Significant appetite control and portion reduction
- Improved energy and mood
- Better sleep quality and recovery
- Enhanced metabolic markers in lab work
Phase 2 represents the core weight loss period where patients make substantial progress toward their goal weight with medical support.
Phase 3: Reaching Goal Weight
Phase 3 is about achieving target weight while optimizing body composition. Patients focus on:
- Final pounds to reach goal weight
- Improving muscle-to-fat ratio
- Establishing sustainable eating patterns
- Transitioning to maintenance protocols
- Addressing any remaining metabolic issues
With medical guidance, patients learn to maintain their results while gradually reducing medication dependence where appropriate.
Phase 4: Long-Term Maintenance
Phase 4 focuses on maintaining weight loss results and preventing regain through:
- Optimized maintenance medication protocols
- Ongoing metabolic monitoring
- Lifestyle integration strategies
- Regular follow-up and adjustment
- Long-term health optimization
At ManUp / WomanUp, we understand that maintaining weight loss is often more challenging than losing weight initially, which is why our medical supervision extends into long-term maintenance.
Why Choose ManUp / WomanUp for Medical Weight Loss?
Patients in the St. Louis region have choices for weight loss programs. Here's what sets our medical approach apart:
- Licensed Medical Expertise – Our fully licensed medical providers can prescribe and monitor controlled substances and combination therapies safely
- Comprehensive Medication Options – Access to both cutting-edge GLP-1 medications and proven traditional treatments
- Combination Therapy Protocols – Ability to combine medications for enhanced results under medical supervision
- Five Convenient Locations – Easily accessible in O'Fallon, St. Peters, Ellisville, Fenton, and Washington, MO
- Personalized Treatment Plans – Every protocol is customized based on your medical history, goals, and response
- Ongoing Medical Supervision – Regular monitoring, lab work, and medication adjustments for optimal results and safety
- Holistic Approach – Integration with hormone therapy, nutritional guidance, and lifestyle optimization when appropriate
Patient Success Stories
Our medical weight loss patients consistently achieve results that seemed impossible through traditional diet and exercise alone. Whether it's a busy professional who lost 60 pounds with semaglutide and phentermine combination therapy, a parent who regained energy and confidence after losing 40 pounds on tirzepatide, or a patient who overcame emotional eating with naltrexone and metformin, the stories share a common theme: medical weight loss provides the physiological reset needed for lasting transformation.
Start Your Medical Weight Loss Journey Today
Whether you're ready to break through weight loss plateaus, overcome persistent cravings, or achieve sustainable results that last, ManUp / WomanUp has the medical expertise and treatment options to guide you.
Take the first step today. Schedule a consultation at one of our five St. Louis-area locations and discover how medical weight loss can help you:
- Achieve significant, sustainable weight loss
- Control appetite and food cravings
- Improve metabolic health and energy
- Boost confidence and quality of life
- Maintain results long-term with medical support
At ManUp / WomanUp, we don't just prescribe weight loss medications—we provide comprehensive medical weight loss transformation that changes lives.