HCG Therapy Updates: FDA Regulations, Treatment Options & Pricing | ManUp/WomanUp

Important Update: Changes to HCG Availability and Testosterone Therapy Options.

At ManUp/WomanUp, your health outcomes and access to optimal hormone replacement therapy remain our top priorities. We want to inform you of recent regulatory developments affecting Human Chorionic Gonadotropin (HCG) therapy and the proactive steps we’ve taken to ensure you continue to receive the highest-quality testosterone replacement therapy (TRT) treatment options.

Understanding the HCG Regulatory Landscape

Federal regulations that took effect in March 2020 reclassified HCG as a biologic, which has made compounded HCG illegal to manufacture or market in the United States. While this change occurred several years ago, enforcement has intensified recently, with many states now requiring clinics to transition exclusively to FDA-approved commercial HCG products. Missouri’s regulatory bodies have now mandated immediate compliance with these federal HCG requirements.

This shift reflects broader patient safety initiatives within the pharmaceutical industry. The FDA has documented Class I recalls for compounded HCG from some compounding pharmacies—recalls indicating serious health risks—underscoring why regulatory oversight has tightened.

HCG Alternatives for Testosterone Replacement Therapy: Your Treatment Options

Our clinical team has worked diligently to secure the most cost-effective, therapeutically sound HCG alternatives available. We’ve successfully negotiated with our trusted 503A and 503B compounding pharmacy partners to offer extremely competitive pricing when compared to average market rates for both hormone therapy options. We’re pleased to provide you with two excellent choices for testosterone optimization:

Option 1: FDA-Approved Commercial HCG for TRT – $180

HCG remains our preferred complement to Testosterone Replacement Therapy (TRT) due to its unique influence on Human Growth Hormone (HGH) production and its comprehensive effects on hormonal optimization. We’ve partnered with reputable suppliers to provide FDA-approved commercial HCG with verified potency, sterility, and quality control. While more expensive than our previous compounded HCG option due to stricter manufacturing requirements and regulatory oversight, our negotiated pricing ensures you’re receiving exceptional value compared to typical market rates for HCG therapy.

Option 2: Enclomiphene for Testosterone Optimization – $100 for 3 Months

Enclomiphene offers proven effectiveness as an HCG alternative with extensive clinical validation. This selective estrogen receptor modulator (SERM) has been studied for years and demonstrates excellent results for patients seeking hormonal optimization and testosterone therapy. Our hormone therapy providers have substantial experience with enclomiphene treatment and can customize your TRT protocol to achieve your specific health goals. Through our pharmacy partnerships, we’ve secured pricing that makes this already cost-effective HCG alternative even more accessible for long-term hormone therapy.

Our Commitment to Quality Hormone Replacement Therapy

Throughout our years serving the men’s health and women’s wellness community, we’ve maintained unwavering dedication to several core principles:

Competitive TRT Pricing: We absorb costs wherever possible and leverage our pharmacy relationships to secure the most competitive pricing available for testosterone therapy and hormone optimization treatments, minimizing the impact on your wallet

Premium Hormone Therapy Products: We source only from verified, compliant suppliers who meet the highest pharmaceutical standards for testosterone and hormone replacement medications

503A and 503B Pharmacy Excellence: We maintain rigorous sourcing standards through FDA-registered 503A and 503B compounding pharmacies for all applicable hormone therapy products. These specialized compounding pharmacies adhere to strict quality control, sterility testing, and purity verification protocols. During this transitional period in the hormone therapy industry, some TRT clinics are not utilizing these premium pharmaceutical sources. This distinction is critical—it ensures that what you purchase from ManUp/WomanUp is always the best testosterone therapy product available in the market, delivered consistently and reliably for your wellbeing. Our continued efforts to partner exclusively with these top-tier compounding facilities means the efficacy and purity of our hormone replacement products is second to none.

Evidence-Based Hormone Therapy: Our TRT treatment recommendations are grounded in current clinical research and individualized to your hormone optimization needs

Transparency in Men’s Health & Wellness Care: We keep you informed about regulatory changes that affect your testosterone therapy and hormone replacement care

This HCG transition was implemented swiftly by Missouri state regulators, but our hormone therapy team immediately mobilized to research HCG alternatives, verify supplier credentials, negotiate favorable pricing, and ensure zero disruption to your testosterone replacement treatment timeline. Your TRT care has remained—and will remain—uninterrupted.

Next Steps for Your Testosterone Therapy

These HCG therapy changes are effective immediately. During your next hormone optimization consultation, your provider will discuss which option best aligns with your testosterone replacement goals, medical history, and budget. Both HCG and enclomiphene options deliver excellent clinical outcomes for hormone therapy, and your TRT provider will help you make the choice that optimizes your individual wellness journey.

We understand that regulatory changes in hormone replacement therapy can feel disruptive, but please know that your health outcomes remain our North Star. Every decision we make—from product sourcing to pricing negotiations—centers on optimizing your testosterone therapy and hormone wellness journey.

Thank you for your continued trust in ManUp/WomanUp for your men’s health and hormone optimization needs. If you have questions about these HCG changes or want to discuss your testosterone replacement therapy options, our patient care team is here to support you.

Questions About HCG Therapy or TRT Options?

Contact any of our area clinics to speak with a member of our hormone therapy patient care team or discuss with your testosterone replacement provider during your next appointment.